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Indium (111In) imciromab (CAT#: TAB-708)

Datasheet
DESCRIPTION CATALOG # SIZE PRICE
Anti-cardiac myosin Recombinant Antibody (Myoscint) TAB-708 1mg Please Inquiry

PRODUCT INFORMATION

  • Product Overview
  • Recombinant mouse monoclonal antibody Fab fragment expressed in CHO binding to human cardiac myosin. Indium (111In) imciromab is a mouse monoclonal antibody and was used for cardiac imaging, but withdrawn in 1993.
  • Target
  • cardiac myosin
  • Type
  • Mouse Fab IgG2a - kappa - kappa
  • Immunogen
  • The details of the immunogen for this antibody are not available.
  • Species Reactivity
  • Human
  • Expression Host
  • Murine ascites, pepsin digestion
  • Applications
  • Suitable for use in ELISA, FC, IP, FuncS, IF, Neut, WB and most other immunological methods.
  • CAS
  • 126132-83-0
  • Trade name
  • Myoscint
  • Molecular Weight
  • Approximately 47 kDa
  • Purity
  • >95.0% as determined by analysis by SDS-PAGE.
  • Size
  • 1mg
  • Storage
  • Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.

BACKGROUND

  • Introduction
  • Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Cardiac MHC exists as two isoforms in humans, alpha-cardiac MHC and beta-cardiac MHC. Th
  • Antigen Description
  • Thus gene encodes the regulatory light chain associated with cardiac myosin beta (or slow) heavy chain. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in this gene are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy.

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